June 2018 - New Protocols

Detailed protocols on genome-editing and fluorescence correlation spectroscopy now available at Nature Protocols.

April 2018 - New Publication

A quantitative map of human Condesins provides new insights into mitotic chromosome architecture

Tagging endogenous Condensin subunits with fluorescent proteins, we map their abundance, physical spacing, and mitotic dynamics by FCS–calibrated live-cell imaging and super-resolution microscopy, and propose a three-step hierarchical loop model of mitotic chromosome compaction.

Also highlighted in EMBL etc.

A JCB spotlight article written by Kazuhiro Maeshima, Kayo Hibino and Damien F. Hudson highlights the importance of Nike's work and was published in April 2018.

Also check out what's new on bioRxiv - Ellenberg Lab Preprints

Web Resource

In the link below from the iBioseminar website, watch Jan Ellenberg explaining how to perform high throughput content imaging screening with an update on the recent technologies developed in our lab and EMBL.

iBioseminar Homepage

Introduction to the Group and its Research

Our group is an international interdisciplinary team drawing its members from biology, physics, chemistry, computer science, and engineering. The overarching theme of the lab is to understand the molecular mechanism of the nuclear division cycle in a comprehensive manner in the physiological context of the intact living cell. To achieve this we develop and use a braod range of fluorescence-based imaging technologies to assay the functions of the involved molecular machinery non-invasively, automate imaging to address all its molecular components and computationally process image data to extract biochemical and biophysical parameters in order to generate mechanistic understanding and predictive models. Our biological questions are currently focused on three areas.